Basic Information
VIS ID
TVIS44013419
Fusion event
HTLV-1-DLG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
196825120/197098249 (Hg38)
End
196825120/197098249 (Hg38)
Orient
+
Location type
Intronic
Target gene
DLG1
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-218-5p ; hsa-mir-9-3p
Nearest miRNA
hsa-let-7g/Upstream/1215854; hsa-mir-4797/Downstream/195629;
Nearest TSS
ENST00000440867/Upstream/12591; ENST00000414529/Downstream/44550;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/67746, chr3-CpG: 115/Downstream/199307
Nearest cancer related gene
DLG1(TSG, No orient, 0)
Upstream sequence
TTCCGAGTTCCTAGTTTCCCTTCATGTTTTGTTTGCTAATTCCTTAAAAGTTCTGCAATGCTTTTTAAATAAGATGTGTATTACATTTCATGTAGCATTA
Downstream sequence
TTAGTTTTTAGCAATTTTGCTGATCTGATTAATAGAAGTCCTAGTGATTTAAGATAGTCTACATTTTAGAAATTTAAAAGCTTTCTGTGTAAAAAGAACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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