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VISDB
Viral Integration Site DataBase
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TVIS44013423
Basic Information
VIS ID
TVIS44013423
Fusion event
HTLV-1-PDE4D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
58410393/59114566 (Hg38)
End
58410393/59114566 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
PDE4D
miRNAs that regulate target gene
hsa-mir-335-5p
;
hsa-mir-340-5p
;
hsa-mir-7-5p
;
hsa-mir-103a-3p
;
hsa-mir-19b-3p
;
hsa-mir-18a-5p
;
hsa-mir-16-5p
;
hsa-mir-3148
;
hsa-mir-4668-5p
;
hsa-mir-4457
;
hsa-mir-5590-3p
;
hsa-mir-142-5p
;
hsa-mir-6783-5p
;
hsa-mir-6838-5p
;
hsa-mir-497-5p
;
hsa-mir-424-5p
;
hsa-mir-195-5p
;
hsa-mir-15b-5p
;
hsa-mir-15a-5p
;
hsa-mir-6835-3p
;
hsa-mir-548z
;
hsa-mir-548h-3p
;
hsa-mir-548d-3p
;
hsa-mir-548bb-3p
;
hsa-mir-7158-3p
;
hsa-mir-548ac
;
hsa-mir-31-3p
;
hsa-mir-302f
;
hsa-mir-4760-3p
;
hsa-mir-4282
;
hsa-mir-18b-5p
;
hsa-mir-4735-3p
;
hsa-mir-4439
;
hsa-mir-3136-5p
;
hsa-mir-6857-3p
;
hsa-mir-6855-3p
;
hsa-mir-4513
;
hsa-mir-4502
;
hsa-mir-4682
;
hsa-mir-1324
;
hsa-mir-4422
;
hsa-mir-3611
;
hsa-mir-4325
;
hsa-mir-4266
;
hsa-mir-642b-3p
;
hsa-mir-642a-3p
;
hsa-mir-6080
;
hsa-mir-6888-5p
;
hsa-mir-3120-3p
;
hsa-mir-3646
;
hsa-mir-424-3p
;
hsa-mir-199a-5p
;
hsa-mir-139-5p
Nearest miRNA
hsa-mir-10397/Upstream/584457; hsa-mir-103a-1/Downstream/589040;
Nearest TSS
ENST00000502646/Upstream/74805;
ENST00000502993/Downstream/101369;
Nearest CpG islands
None/Target,
chr5-CpG: 87/Upstream/74512
,
chr5-CpG: 47/Downstream/778653
Upstream sequence
ctcagttgggaatttccaataaatattggggttccaagctttgcagaagaggttaagatggatttctatataaatttaggggctttcagcaaacaggtgg
Downstream sequence
taattaaaataagaatgcacaagtcagtcttggaagacacacagagtgaggaaagcaggaatggagaatgggatcctgggaaccccaggtcaaaggaagg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Sample Information
×
Sample name
ATL227
Sample type
Nontumor
Gender
Female
CpG Island Information
×
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