Basic Information
VIS ID
TVIS44013426
Fusion event
HTLV-1-chr9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
5324097/5324097 (Hg38)
End
5324097/5324097 (Hg38)
Orient
+
Location type
Intronic
Target gene
RLN1 ; RLN2
miRNAs that regulate target gene
hsa-mir-4453 ; hsa-mir-4538 ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-548n ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-6505-5p ; hsa-mir-7156-3p ; hsa-mir-4789-5p ; hsa-mir-7153-3p ; hsa-mir-8084 ; hsa-mir-6509-5p ; hsa-mir-4795-3p ; hsa-mir-3924 ; hsa-mir-331-5p ; hsa-mir-4742-3p ; hsa-mir-1183 ; hsa-mir-1258
Nearest miRNA
hsa-mir-101-2/Upstream/473722; hsa-let-7a-1/Downstream/683729;
Nearest TSS
ENST00000422679/Upstream/19128; ENST00000474218/Downstream/15299;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/19621, chr9-CpG: 45/Downstream/14929
Nearby gene
RLN1(-10835) ;
Upstream sequence
gatcacaccactgcactccagtctgggcaacagagtaagactctgtctcaaaataaataaataaataaataaaAGATGTAATTCCAATCAGCTCTTAAGG
Downstream sequence
TGGTGGTAGTCATTTTTATTGTTATATGTGCAAAAAAAATCACCAATATTTGTGGGTAGATTAGCAGTTACTAATGTTAAAGTGCAGGGTCTACAGCTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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