Basic Information
VIS ID
TVIS44013427
Fusion event
HTLV-1-PLPPR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
103969458/101207176 (Hg38)
End
103969458/101207176 (Hg38)
Orient
+
Location type
Intronic
Target gene
PLPPR1
Nearest miRNA
hsa-let-7a-1/Upstream/2977959; hsa-mir-12126/Downstream/5393752;
Nearest TSS
ENST00000422679/Upstream/22141; ENST00000463206/Downstream/62626;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/177694, chr9-CpG: 49/Downstream/191395
Upstream sequence
tataatttataattatcttaatttttatttGCCTACTTTTTTATTGTGTGTATATATCTTTCACAGACTATAAACTCCATATCTGACAAATGCAAAATAC
Downstream sequence
TGAATAAATATTGGCTCAGGGAATGAGTAGATAAACCTTTAAAAAAAATCTAAATATTCAAACTTTTTCTTTCCCCTCACTAATTCCTCTTAAAAAAGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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