Basic Information
VIS ID
TVIS44013436
Fusion event
HTLV-1-UFM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
38927720/38353583 (Hg38)
End
38927720/38353583 (Hg38)
Orient
+
Location type
Intronic
Target gene
UFM1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-129-5p ; hsa-mir-3942-3p ; hsa-mir-5100 ; hsa-mir-7641 ; hsa-mir-27b-5p ; hsa-mir-1288-5p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-6756-3p ; hsa-mir-6818-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-6728-3p ; hsa-mir-7113-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-5582-3p ; hsa-mir-339-5p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-2355-5p ; hsa-mir-27a-5p ; hsa-mir-3124-3p ; hsa-mir-378g ; hsa-mir-6860 ; hsa-mir-4486 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-1298-3p
Nearest miRNA
hsa-mir-2276/Upstream/14191079; hsa-mir-1267/Downstream/1310451;
Nearest TSS
ENST00000623511/Upstream/3587; ENST00000441430/Downstream/191716;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/3307, chr13-CpG: 99/Downstream/333516
Upstream sequence
TTGATTTTTTTTATTGGAAAGTTCATACAGATTGACCCTGGGACTAAGTCATTAAGAAAAAAAAAATATATTTATTCATGATCTTTAAAATACTTGCCGT
Downstream sequence
TATATGAGTCAGTTAACAAAATCACTCATCCCTCTCCAAAATGTTATTTCACATTTTACTTAGCCCACTTTAAATGATGGTAGAAAAATCACTTCATTAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate