Basic Information
VIS ID
TVIS44013454
Fusion event
HTLV-1-MCOLN3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
85493744/85028061 (Hg38)
End
85493744/85028061 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
MCOLN3
miRNAs that regulate target gene
hsa-mir-4668-5p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-605-5p ; hsa-mir-4668-3p ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-101-1/Upstream/7967859; hsa-mir-11399/Downstream/105733;
Nearest TSS
ENST00000473358/Upstream/4541; ENST00000528899/Downstream/1898;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/29577, chr1-CpG: 114/Downstream/19765
Upstream sequence
CCATTAGTATCTGCCAAGGAGCATAATTACTACATAAATGTCTAAATTGACTTTAGAGAAACTTACAAATTAAGAAACAAACATTTGAGAGAATGCCTAG
Downstream sequence
GTGCCAGACACTTGTGTATGCTGTCATTTTCCTCATTCTGGTGTTTGTGGAGAATGATTATAAAGTATACAGATGACAAAACAGGCTTATGTTTCAAATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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