Basic Information
VIS ID
TVIS44013458
Fusion event
HTLV-1-PGR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
100913594/101042863 (Hg38)
End
100913594/101042863 (Hg38)
Orient
-
Location type
Intronic
Target gene
PGR
miRNAs that regulate target gene
hsa-mir-126-3p ; hsa-mir-181a-5p ; hsa-mir-378a-3p
Nearest miRNA
hsa-mir-10392/Upstream/4701337; hsa-let-7a-2/Downstream/476957;
Nearest TSS
ENST00000527297/Upstream/50783; ENST00000532529/Downstream/8607;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/355193, chr11-CpG: 170/Downstream/84436
Nearest cancer related gene
PGR(TSG, No orient, 0)
Upstream sequence
aatcacatgcatctttttgtttcccagtccacgtagaagttatatttacactatactagaatgtattaagtgtgcaacagcattatttaaaaagtgaaca
Downstream sequence
caccttaactaaaaaacactttattgctagaaaatggtaacaatcatctgagtcttccctgagtcaaaatctttttgctgttggagggtgttgtctaaat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate