Basic Information
VIS ID
TVIS44013481
Fusion event
HTLV-1-NSUN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
6620163/6620050 (Hg38)
End
6620163/6620050 (Hg38)
Orient
-
Location type
Intronic
Target gene
NSUN2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-193b-3p ; hsa-mir-149-5p ; hsa-mir-125b-5p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-1260b ; hsa-mir-21-5p
Nearest miRNA
hsa-mir-4277/Upstream/4911182; hsa-mir-10397/Downstream/207803;
Nearest TSS
ENST00000502646/Upstream/12793; ENST00000504286/Downstream/1439;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/36356, chr5-CpG: 149/Downstream/12577
Upstream sequence
TACGTGTCCATCTTTTGGTTTAGGCTCACGCTATCTTTCTCCGCACCCCAAGACTTATGTACAATTGTGTCATATTCATGCACAACTTCATTTTAGTCTC
Downstream sequence
TATTTGACTTGATTTCTTTAGTGGATTTGGGCTTTTTGGCCAATAAGATAAATACCTGCAAGGGACATCACATAAAATTCGATCATAGAAGAGGATCTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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