VISDB - VIS Detail

Basic Information

VIS ID

TVIS44013498

Fusion event

HTLV-1-TRIM37 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr17

Cytoband

q22

Reference genome

GRCh37/hg19

Start

57070829/58993468 (Hg38)

End

57070829/58993468 (Hg38)

Orient

Location type

Intronic

Target gene

TRIM37

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-769-3p ; hsa-mir-30e-3p ; hsa-mir-183-5p ; hsa-mir-937-5p ; hsa-mir-4291 ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-4696 ; hsa-mir-5702 ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-545-3p ; hsa-mir-1179 ; hsa-mir-451b ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-7-2-3p ; hsa-mir-5688 ; hsa-mir-7-1-3p ; hsa-mir-495-3p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-7844-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-106b-5p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106a-5p ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-301b-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-454-3p ; hsa-mir-301a-3p ; hsa-mir-142-3p ; hsa-mir-519d-5p ; hsa-mir-6080 ; hsa-mir-622 ; hsa-mir-4255 ; hsa-mir-6888-5p ; hsa-mir-4428

Nearest miRNA

hsa-mir-10226/Upstream/657446; hsa-mir-1250/Downstream/144290;

Nearest TSS

ENST00000595228/Upstream/237599; ENST00000451775/Downstream/18939;

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/236732, chr17-CpG: 87/Downstream/112799

Upstream sequence

acaagagtctaatcaccctaaactagaaataacccaaatgggcaaatgaatgaacagtggtatatccacacagtggactactactgctcagcaataaaaa

Downstream sequence

agaaggaggtgctgattcacacaagatgagtgaaacttaactgcactttgcgaagcgagaggtcaaactgtgatcccgtttacatgactctggaaaagca

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.