Basic Information
VIS ID
TVIS44013509
Fusion event
HTLV-1-GOLGB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
121469869/121751022 (Hg38)
End
121469869/121751022 (Hg38)
Orient
-
Location type
Intronic
Target gene
GOLGB1
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-335-5p ; hsa-mir-544a ; hsa-mir-218-5p
Nearest miRNA
hsa-let-7g/Upstream/701307; hsa-mir-12124/Downstream/1410772;
Nearest TSS
ENST00000440867/Upstream/1255; ENST00000465664/Downstream/83970;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1291, chr3-CpG: 42/Downstream/83951
Nearby gene
GOLGB1(-1255) ;
Upstream sequence
agatagaaggaataagttcaagtgtttgatagcacagtagggtgactatagttaacaatatgttatatatttcaaaataactaggagattagaaatgttc
Downstream sequence
caaacacaaaaatgataaatgtttgaggtgatagatatcctaaacaccctgatttgatcattacacattgtatgcatatatcaaactaccacaccccata
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate