Basic Information
VIS ID
TVIS44013529
Fusion event
HTLV-1-GNG2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
52331357/51864639 (Hg38)
End
52331357/51864639 (Hg38)
Orient
-
Location type
Intronic
Target gene
GNG2
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-629-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-6881-3p ; hsa-mir-222-5p ; hsa-mir-942-5p ; hsa-mir-877-3p ; hsa-mir-16-1-3p
Nearest miRNA
hsa-mir-208a/Upstream/1564693; hsa-mir-1185-1/Downstream/2083788;
Nearest TSS
ENST00000550708/Upstream/3315; ENST00000556471/Downstream/12953;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/211869, chr14-CpG: 60/Downstream/124771
Upstream sequence
GAAATCAAAAGGACAGAGTAAGAAAATGTGCATAGCTTCTGCTAGTTGGTGATGTCCAGAACCTGATAGTGAAATTCAAACCTTTATTGTAGACAGTCAC
Downstream sequence
ACCAGTGATTCTGCTGGTCAAATCTCAGACCAGGCTACCACTACGGAGGCACTGGAGAGCTGTTTCTTCAGTGCTTTTCTGGTCCCCTCATTAGAGAAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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