Basic Information
VIS ID
TVIS44013532
Fusion event
HTLV-1-FAM234A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
303894/253895 (Hg38)
End
303894/253895 (Hg38)
Orient
+
Location type
Intronic
Target gene
FAM234A
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-320b ; hsa-mir-320a ; hsa-mir-4728-5p ; hsa-mir-3175 ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-3202 ; hsa-mir-3663-3p ; hsa-mir-6125 ; hsa-mir-3179
Nearest miRNA
hsa-mir-6859-4/Upstream/236776; hsa-mir-11401/Downstream/281421;
Nearest TSS
ENST00000527434/Upstream/4348; ENST00000496874/Downstream/227;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/18499, chr16-CpG: 26/Downstream/14723
Upstream sequence
gaacaggcttctaaagtagatattgtttgttttacagataaggaaactgaggcacagttcagtcaaagcacatgtcctggtcacacagctagggaggtgc
Downstream sequence
aagcctgcccgcccagagcccatcttcactccgggtACTTTGAATTTTGGGTCTGTGGCCCTCCAGGGAGTCCATGTGTGCGCACCTGGGTCACCTTTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate