Basic Information
VIS ID
TVIS44013546
Fusion event
HTLV-1-PGGT1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
114573814/115238117 (Hg38)
End
114573814/115238117 (Hg38)
Orient
+
Location type
Intronic
Target gene
PGGT1B
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-591 ; hsa-mir-582-3p ; hsa-mir-582-5p ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-4795-5p ; hsa-mir-4282 ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-487b-5p ; hsa-mir-487a-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-3614-5p ; hsa-mir-942-3p ; hsa-mir-4802-3p ; hsa-mir-1276
Nearest miRNA
hsa-mir-10397/Upstream/4724202; hsa-mir-103a-1/Downstream/1017626;
Nearest TSS
ENST00000502646/Upstream/6333; ENST00000606615/Downstream/15059;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/57594, chr5-CpG: 35/Downstream/24487
Upstream sequence
AAAATTAATATAGTACTAATTAATGAAGTGAAATGAAAACTTATTTCATTAAGAAATCTGACATAAGGTTTTAGTAAATAGTAAAATTAAATATGGCTTA
Downstream sequence
TACTGATTTGTATAGACATCTTATTGAGAAAAACAAATCTCCATTTTATGTATGTCTCAATATGAATATGATTGCACAGGCTACTTAATCTTTAAATTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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