Basic Information
VIS ID
TVIS44013554
Fusion event
HTLV-1-CFAP77 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.13
Reference genome
GRCh37/hg19
Start
135363608/132488221 (Hg38)
End
135363608/132488221 (Hg38)
Orient
+
Location type
Intronic
Target gene
CFAP77
miRNAs that regulate target gene
hsa-mir-3157-3p ; hsa-mir-4792 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-4763-5p ; hsa-mir-18b-3p ; hsa-mir-1827 ; hsa-mir-6823-3p ; hsa-mir-2114-3p ; hsa-mir-18a-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-596
Nearest miRNA
hsa-let-7a-1/Upstream/1861858; hsa-mir-126/Downstream/457486;
Nearest TSS
ENST00000422679/Upstream/77993; ENST00000542090/Downstream/93964;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1127, chr9-CpG: 230/Downstream/91556
Upstream sequence
ATTAGTTTAGACGCAGGGCTGGAGGGTTAATGAGCTACACTATATGTGGTTGCCAGGAAGTGGGGAGTGATTGATTCCTTTGAGGGGCTAGCTCGTGATG
Downstream sequence
GAATGAACGTCTTTGGTGGGTCTGACACTCAGGCATCGAGCTCCCTGACAGAAAACCTGCCACTTTGGAAGTGACCACTGGCCCGTTTGTCTGGAATAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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