Basic Information
VIS ID
TVIS44013555
Fusion event
HTLV-1-ZC4H2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
64210338/64990458 (Hg38)
End
64210338/64990458 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZC4H2
miRNAs that regulate target gene
hsa-mir-152-5p ; hsa-mir-597-3p ; hsa-mir-182-3p ; hsa-mir-4539 ; hsa-mir-218-2-3p
Nearest miRNA
hsa-let-7f-2/Upstream/1204371; hsa-mir-105-1/Downstream/1028412;
Nearest TSS
ENST00000429181/Upstream/13925; ENST00000617377/Downstream/44211;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/594915, chrX-CpG: 78/Downstream/44070
Upstream sequence
ggaatggtagtgggagggaagtaggtgtggctataaaagggcaatatgagggttccttgtggtggtggaaatgttctgtatcttgattatattaatgtca
Downstream sequence
atatcttctctgtggtattgtactatagttctgcaaggggttactattggggaaaacagagtacaatttacatgagatctatctgtatcatttttctgca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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