Basic Information
VIS ID
TVIS44013571
Fusion event
HTLV-1-HNRNPH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
GRCh37/hg19
Start
179055951/179628950 (Hg38)
End
179055951/179628950 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
HNRNPH1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-21-5p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-331-3p ; hsa-mir-149-5p ; hsa-mir-222-3p ; hsa-mir-30d-5p ; hsa-mir-197-3p ; hsa-mir-1245a ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-2355-5p ; hsa-mir-383-5p ; hsa-mir-4262 ; hsa-mir-4275 ; hsa-mir-4276 ; hsa-mir-4697-3p ; hsa-mir-4772-5p ; hsa-mir-5190 ; hsa-mir-5702 ; hsa-mir-8079
Nearest miRNA
hsa-mir-10397/Upstream/2999450; hsa-mir-1229/Downstream/169328;
Nearest TSS
ENST00000502646/Upstream/4281; ENST00000508188/Downstream/5490;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/4340, chr5-CpG: 39/Downstream/3386
Nearby gene
HNRNPH1(-5229) ;
Upstream sequence
tacgtctgtaatcccagctacacaggagtgtgaggtgggaggatggcttgaaccccagagacagaggttgcagtgagccaagatcacaccactgcactcc
Downstream sequence
agcctaggtgacagagcgagactgtgcctcaaagaaaagaaaataaaTGCAATCATAAATAACCCggctgggcgcggcggctcacgcctgtaatcccagc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate