Basic Information
VIS ID
TVIS44013574
Fusion event
HTLV-1-EPHA7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh37/hg19
Start
94033227/93323509 (Hg38)
End
94033227/93323509 (Hg38)
Orient
-
Location type
Intronic
Target gene
EPHA7
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-93-5p ; hsa-mir-455-3p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-548c-3p ; hsa-mir-590-3p ; hsa-mir-8061 ; hsa-mir-4775 ; hsa-mir-4760-5p ; hsa-mir-3934-3p ; hsa-mir-4330 ; hsa-mir-10b-3p ; hsa-mir-577 ; hsa-mir-6757-3p ; hsa-mir-141-3p ; hsa-mir-200a-3p
Nearest miRNA
hsa-mir-10398/Upstream/1801772; hsa-mir-1202/Downstream/4701022;
Nearest TSS
ENST00000381078/Upstream/253122; ENST00000424678/Downstream/96017;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2712009, chr6-CpG: 92/Downstream/93045
Upstream sequence
TTACAGTTTAGCTCAAGAAACCAAAATAATGATACCAAATATACAGAATATAAAGTTCTGGGAAATGTGCATGTTTATTGTACACGTACAAATATATACT
Downstream sequence
ATTCATTAGGTACTAAGTTTTAACACACAAAGTAGCATGTTTTTCCTGGCCTACTAGAATCAAGATTTTGGAAAGGCAGATGTTTGACAATTTTATTTAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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