Basic Information
VIS ID
TVIS44013575
Fusion event
HTLV-1-RELN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
103596834/103956387 (Hg38)
End
103596834/103956387 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
RELN
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-138-5p ; hsa-mir-10a-5p
Nearest miRNA
hsa-mir-10525/Upstream/1484856; hsa-mir-10399/Downstream/10696958;
Nearest TSS
ENST00000635602/Upstream/326251; ENST00000401970/Downstream/33129;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/509994, chr7-CpG: 122/Downstream/32691
Upstream sequence
TGAAATGAATAGCTTTCCTGAAAGATGTGCAAACACAGTAAAACTGATTTTAGTGTTAAGTGTTCAATAAAGAAACAAAGTAACAACACTGCTGAAGTAA
Downstream sequence
TCTCCTGTAAAGAAAAGACCAGGATAAACCCAAACAAAATTTTAGAAACAGACACGAAATGAGAGTTCTAATCAGCACAACAGAAAAGTATATCCTTACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate