Basic Information
VIS ID
TVIS44013588
Fusion event
HTLV-1-TNRC18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
5461728/5422097 (Hg38)
End
5461728/5422097 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
TNRC18
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-34a-5p ; hsa-mir-1307-3p ; hsa-mir-455-3p ; hsa-mir-615-3p ; hsa-mir-92a-3p ; hsa-mir-218-5p ; hsa-mir-142-3p ; hsa-mir-193b-5p ; hsa-mir-20b-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-3065-3p ; hsa-mir-3137 ; hsa-mir-3170 ; hsa-mir-3686 ; hsa-mir-383-3p ; hsa-mir-4291 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-5572 ; hsa-mir-6737-5p ; hsa-mir-6812-5p ; hsa-mir-6819-5p ; hsa-mir-6855-5p ; hsa-mir-767-5p
Nearest miRNA
hsa-mir-339/Upstream/633458; hsa-mir-10399/Downstream/73722;
Nearest TSS
ENST00000635602/Upstream/2251; ENST00000609130/Downstream/1449;
Nearest CpG islands
chr7-CpG: 711/Target, None/Upstream, None/Downstream
Upstream sequence
GAGCTCGCCTTGAACCGCCGACGGAATGGTGTTTTTCTGGGGGTGGGAGGAGGGAGGGTCCAAAGCGGGTTTATTATTTTTAAAGAGGCTCGTGGTCCCC
Downstream sequence
CCCCTTTCTCCCCCCGGGGGGCACTGTGAGTCCCAGAGCTCGAGTCCGAGGACCCGAGACGTGGCATTCTCGCCTAAGGACTGGAAAGAATCCTACAAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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