Basic Information
VIS ID
TVIS44013593
Fusion event
HTLV-1-PPFIA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
81907931/81514152 (Hg38)
End
81907931/81514152 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
PPFIA2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7i/Upstream/355691; hsa-mir-1178/Downstream/5230916;
Nearest TSS
ENST00000382841/Upstream/1768; ENST00000550506/Downstream/84104;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/435812, chr12-CpG: 34/Downstream/244389
Upstream sequence
CAGATTGATTTGGAATTGTTACAACAGACAAAAAATCTTTTATCTCTGCCTCACTAGAACTTCCAGAATTTAATTAAAATTTATTCATTGATTCTGCCCT
Downstream sequence
CTTCTATCCCAGTCAAGTTCCCCCCCTGAACAAATACAGTATATAGGGTCAGTGCAATGAGCAGAATTGCTCAGAAAATGTCCTCTCTCCTATTAACCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate