Basic Information
VIS ID
TVIS44013597
Fusion event
HTLV-1-KDM6B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
End
7739256/7835938 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-186-5p ; hsa-mir-101-3p ; hsa-mir-18a-3p ; hsa-mir-92a-3p ; hsa-let-7a-5p ; hsa-mir-5787 ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-941 ; hsa-mir-127-5p ; hsa-mir-3175 ; hsa-mir-3178 ; hsa-mir-6731-5p ; hsa-mir-8085 ; hsa-mir-4749-5p ; hsa-mir-4706 ; hsa-mir-2277-5p ; hsa-mir-4746-5p ; hsa-mir-6889-5p ; hsa-mir-6777-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-3940-3p ; hsa-mir-7109-5p ; hsa-mir-4472 ; hsa-mir-6771-5p ; hsa-mir-4447 ; hsa-mir-7704 ; hsa-mir-615-5p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-4652-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-4515 ; hsa-mir-4745-5p ; hsa-mir-4481 ; hsa-mir-7152-3p ; hsa-mir-6746-5p ; hsa-mir-1296-3p ; hsa-mir-1203 ; hsa-mir-1267 ; hsa-mir-1286 ; hsa-mir-146a-5p ; hsa-mir-146b-5p ; hsa-mir-149-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-3135b ; hsa-mir-3648 ; hsa-mir-3652 ; hsa-mir-3663-3p ; hsa-mir-367-5p ; hsa-mir-4430 ; hsa-mir-4501 ; hsa-mir-4711-3p ; hsa-mir-4722-5p ; hsa-mir-4728-5p ; hsa-mir-4767 ; hsa-mir-505-5p ; hsa-mir-519a-3p ; hsa-mir-519b-3p ; hsa-mir-519c-3p ; hsa-mir-581 ; hsa-mir-589-5p ; hsa-mir-592 ; hsa-mir-6090 ; hsa-mir-6783-5p ; hsa-mir-6785-5p ; hsa-mir-6808-3p ; hsa-mir-6824-5p ; hsa-mir-6825-5p ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-6883-5p ; hsa-mir-7153-5p ; hsa-mir-767-5p ; hsa-mir-7973 ; hsa-mir-8055 ; hsa-mir-873-5p ; hsa-mir-1178-3p ; hsa-mir-125a-3p ; hsa-mir-143-5p ; hsa-mir-148a-3p ; hsa-mir-148b-3p ; hsa-mir-152-3p ; hsa-mir-185-3p ; hsa-mir-1913 ; hsa-mir-210-5p ; hsa-mir-3151-5p ; hsa-mir-324-3p ; hsa-mir-331-3p ; hsa-mir-3620-3p ; hsa-mir-381-5p ; hsa-mir-3934-5p ; hsa-mir-423-5p ; hsa-mir-4283 ; hsa-mir-4433a-3p ; hsa-mir-4466 ; hsa-mir-4489 ; hsa-mir-4492 ; hsa-mir-4498 ; hsa-mir-4505 ; hsa-mir-4524a-3p ; hsa-mir-4700-3p ; hsa-mir-4731-5p ; hsa-mir-4737 ; hsa-mir-4749-3p ; hsa-mir-486-3p ; hsa-mir-5001-5p ; hsa-mir-6499-3p ; hsa-mir-675-5p ; hsa-mir-6784-3p ; hsa-mir-6804-5p ; hsa-mir-6852-5p ; hsa-mir-6862-3p ; hsa-mir-6865-3p ; hsa-mir-762 ; hsa-mir-764 ; hsa-mir-92a-2-5p
Nearest miRNA
hsa-mir-1253/Upstream/612559; hsa-mir-10226/Downstream/252118;
Nearest CpG islands
chr17-CpG: 136/Target, None/Upstream, None/Downstream
Nearby gene
DNAH2(+2194) ;
Upstream sequence
CCGCCTGAGGCTGCGCTCTTCAGCCCCTGGGGACCCACACGTCTCGGTCGGTCTGCACCGTTTCGCCGGTCGCGACCATAATGCCCAGCCTGGCTCGGGA
Downstream sequence
GGGCCGACTACCTGTTCCCCACCTCCCCCCAGCTGGCGCCCCACACTCCCAGGTGGGCTGGGCGGAGCTGTGGTTTCCGGCCCCATCTGCTCGGCCGCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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