Basic Information
VIS ID
TVIS44013631
Fusion event
HTLV-1-DENND2D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
111743427/111200805 (Hg38)
End
111743427/111200805 (Hg38)
Orient
+
Location type
Intronic
Target gene
DENND2D
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-522-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1601838; hsa-mir-11399/Downstream/1260965;
Nearest TSS
ENST00000473358/Upstream/34; ENST00000530597/Downstream/3497;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/60124, chr1-CpG: 91/Downstream/2886
Nearest cancer related gene
DENND2D(TSG, No orient, 0)
Upstream sequence
AGCGCAGATCTCAGCTCCTCCCAAGAGCCCCAGGGTGTGGCGAGAGAAAAGGTCATGAGCAAACACCTCTGGCTGAAAGTAGCCGGAAAGGCCTGGCTAC
Downstream sequence
TTATGGGCTAAGGGTTTTGAATCTGGGCTGCAGATTGTGCAGAGAGTTAATTTACAACCTTAGAACAGTGGACAATGCTTGATAGTGTCAGACTGTGGGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate