VISDB - VIS Detail

Basic Information

VIS ID

TVIS44013633

Fusion event

HTLV-1-PPP6R3 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr11

Cytoband

q13.2

Reference genome

GRCh37/hg19

Start

68315610/68548142 (Hg38)

End

68315610/68548142 (Hg38)

Orient

Location type

Exonic

Fragile sites / regions

FRA11H ; FRA11A

Target gene

PPP6R3

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-34a-5p ; hsa-mir-103a-3p ; hsa-mir-615-3p ; hsa-mir-20a-5p ; hsa-mir-624-3p ; hsa-mir-17-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-130a-3p ; hsa-mir-106b-5p ; hsa-mir-301a-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-552-5p ; hsa-mir-652-5p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-548t-5p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-548ao-5p ; hsa-mir-548ax ; hsa-mir-548az-5p ; hsa-mir-7854-3p ; hsa-mir-759 ; hsa-mir-3174 ; hsa-mir-3678-3p ; hsa-mir-3944-5p ; hsa-mir-4519 ; hsa-mir-2467-3p ; hsa-mir-5586-3p ; hsa-mir-1273h-3p ; hsa-mir-623 ; hsa-mir-542-3p ; hsa-mir-107 ; hsa-mir-1909-5p ; hsa-mir-2277-3p ; hsa-mir-6780b-3p ; hsa-mir-6841-3p ; hsa-mir-4780 ; hsa-mir-5190 ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-4696 ; hsa-mir-5585-5p ; hsa-mir-32-3p ; hsa-mir-548n ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-214-3p ; hsa-mir-3619-5p ; hsa-mir-424-5p ; hsa-mir-4264 ; hsa-mir-4291 ; hsa-mir-4704-3p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-761 ; hsa-mir-922

Nearest miRNA

hsa-mir-10392/Upstream/503185; hsa-let-7a-2/Downstream/535034;

Nearest TSS

ENST00000527297/Upstream/10326; ENST00000531432/Downstream/10054;

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/87034, chr11-CpG: 28/Downstream/122029

Upstream sequence

AGTTTCTGATCTGTTCTTCTCTAGATTGTGGATTTCTTAAAGAAGAAGCATGATTTTGTAGACCTTATTATAAAGCACATAGGAACTTCTGCTATCATGG

Downstream sequence

ATTTGTTGCTCAGGCTCCTGACGTGTATCGAACCTCCACAGCCCAGGCAAGATGTGCTGAATGTGAGTAGAATTCTGACCTGCTGTTGACTGGGGTTAGG

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.