Basic Information
VIS ID
TVIS44013637
Fusion event
HTLV-1-GRIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
67438961/67045181 (Hg38)
End
67438961/67045181 (Hg38)
Orient
-
Location type
Intronic
Target gene
GRIP1
Nearest miRNA
hsa-let-7i/Upstream/794024; hsa-mir-1178/Downstream/2227976;
Nearest TSS
ENST00000382841/Upstream/240995; ENST00000539109/Downstream/23981;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/809557, chr12-CpG: 105/Downstream/23709
Nearby gene
LOC102724421(No orient, 32445)
Upstream sequence
aacactaCTTGAGCTAAGCTGCAGAAAATGTAACACAGCACATTGGAGATGGGATTCAAAATCATGTTTAGAAAAAGATAATCAAGATTCCCAAGTTACC
Downstream sequence
CACTGGGAAGAGTGGGTAACTTTATTCTCTGATTTTTTCAATGAAGTAATTAGTCAGCAAAATCCTGTTGATTCAGTGTCAGGTAAAGAAATAGGGATAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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