Basic Information
VIS ID
TVIS44013672
Fusion event
HTLV-1-PARP8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
50116133/50820299 (Hg38)
End
50116133/50820299 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
PARP8
miRNAs that regulate target gene
hsa-mir-145-5p
Nearest miRNA
hsa-mir-10397/Upstream/12262738; hsa-mir-103a-1/Downstream/3131205;
Nearest TSS
ENST00000502646/Upstream/152406; ENST00000508923/Downstream/39721;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/152356, chr5-CpG: 53/Downstream/148952
Upstream sequence
TAGGTCACAATACTCCTCTCTTAGAAGCAGGACAATCAAAAATTGGCCCCCTCTTACTGTGCATTTTTTAAATGCCTGTCTAAAGACTTTCTAGAAATAG
Downstream sequence
CTTTCCCTATAAAGATATATATGCTTCCTTATTAAGTCACTTGTGTTCACACTGTAGATATGTCTGTTCAGGTGAACTCTGACCATTTAGGCAGTATCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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