VISDB - VIS Detail

Basic Information

VIS ID

TVIS44013679

Fusion event

HTLV-1-IGF2R integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr6

Cytoband

q25.3

Reference genome

GRCh37/hg19

Start

160435514/160014482 (Hg38)

End

160435514/160014482 (Hg38)

Orient

Location type

Intronic

Target gene

IGF2R

miRNAs that regulate target gene

hsa-mir-16-5p ; hsa-mir-657 ; hsa-mir-155-5p ; hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-1271-5p ; hsa-mir-423-3p ; hsa-mir-128-3p ; hsa-mir-211-5p ; hsa-mir-545-5p ; hsa-mir-412-3p ; hsa-mir-377-3p ; hsa-mir-218-5p ; hsa-mir-96-3p ; hsa-mir-2681-3p ; hsa-mir-548m ; hsa-mir-8485 ; hsa-mir-7977 ; hsa-mir-4284 ; hsa-mir-24-3p ; hsa-mir-564 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-383-3p ; hsa-mir-342-3p ; hsa-mir-6777-3p ; hsa-mir-6089 ; hsa-mir-561-5p ; hsa-mir-6715b-3p ; hsa-mir-4742-3p ; hsa-mir-6715a-3p ; hsa-mir-1178-5p ; hsa-mir-649 ; hsa-mir-106a-3p ; hsa-mir-1296-5p ; hsa-mir-6877-5p ; hsa-mir-4480 ; hsa-mir-5008-5p ; hsa-mir-3146 ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-4512 ; hsa-mir-6895-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-1247-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-3612 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4756-3p ; hsa-mir-5186 ; hsa-mir-5694 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-4252 ; hsa-mir-4719 ; hsa-mir-551b-5p

Nearest miRNA

hsa-mir-10398/Upstream/1249729; hsa-mir-1913/Downstream/6494872;

Nearest TSS

ENST00000381078/Upstream/4144; ENST00000487607/Downstream/58934;

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/8012, chr6-CpG: 43/Downstream/76422

Nearest cancer related gene

IGF2R(TSG, No orient, 0)

Upstream sequence

GTGGGAGGGTGTTCCCCAGTAGCCTTGACTGTTTACCAATGCACACTCCAGTTCTGTGGAGTGCTGTGTGAGGCATGTCTTCTCTTCCCTCCTGGAGTAG

Downstream sequence

GGAGACAGCCAGTAGTTGCTACCTGCCCCGAGCAGGGTGCTTGCAGATCTTGCCTATGTGGAATCCTCTAAGTGTCTTGGTGAAATGCAGCTGTTTTCAG

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.