Basic Information
VIS ID
TVIS44013694
Fusion event
HTLV-1-CCNY integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
35841160/35552232 (Hg38)
End
35841160/35552232 (Hg38)
Orient
-
Location type
Intronic
Target gene
CCNY
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-let-7b-5p ; hsa-mir-744-5p ; hsa-mir-93-3p ; hsa-mir-193b-3p ; hsa-mir-4669 ; hsa-mir-6516-5p ; hsa-mir-6751-5p ; hsa-mir-6803-5p ; hsa-mir-455-3p ; hsa-mir-4497 ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6499-3p ; hsa-mir-6835-5p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-4795-5p ; hsa-mir-1296-3p ; hsa-mir-298 ; hsa-mir-4696 ; hsa-mir-1252-5p ; hsa-mir-186-3p ; hsa-mir-922 ; hsa-mir-4733-5p ; hsa-mir-3613-3p
Nearest miRNA
hsa-mir-1265/Upstream/472552; hsa-mir-107/Downstream/88940;
Nearest TSS
ENST00000439456/Upstream/22036; ENST00000321660/Downstream/53178;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/214620, chr10-CpG: 75/Downstream/55358
Upstream sequence
cagaagaatggataaacatgatggtgtatatgcatacagctgaatattattcagccttaaaaaggaagttctgacccatgccacaacatgggtgaacctt
Downstream sequence
gaggtcattatgcgaagtgataataagccagacagaaaaggacgaatattttattattctaccaatatgatgtgccaagagtagtcagattcatagagaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate