Basic Information
VIS ID
TVIS44013714
Fusion event
HTLV-1-TARSL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
102230317/101690114 (Hg38)
End
102230317/101690114 (Hg38)
Orient
-
Location type
Intronic
Target gene
TARSL2
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-10393/Upstream/2905612; hsa-mir-1302-10/Downstream/270345;
Nearest TSS
ENST00000557528/Upstream/25672; ENST00000328882/Downstream/11051;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/36972, chr15-CpG: 75/Downstream/33873
Upstream sequence
CCAATGGCACGATTCAGATTTAGGTGAAACTGAAATGACATCACCACATGATGACACATCGGCTGATCGGAGTTTGTGGGAGGAAACCAATGTCCTCAGT
Downstream sequence
GTCCTCCAAGCAAAAGGCAAGAATGTGCTGAGAGGCACAGGGGGTGAGCCAGGCTGGTTATTTTCCATTTGCCACTGCCTGTCTCGCCTCATCTTGGCCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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