Basic Information
VIS ID
TVIS44013719
Fusion event
HTLV-1-NCOA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
24792921/24570052 (Hg38)
End
24792921/24570052 (Hg38)
Orient
-
Location type
Intronic
Target gene
NCOA1
miRNAs that regulate target gene
hsa-mir-22-3p ; hsa-let-7d-5p ; hsa-mir-34a-5p ; hsa-mir-548e-5p ; hsa-mir-105-5p ; hsa-mir-129-5p ; hsa-mir-3158-5p ; hsa-mir-3185 ; hsa-mir-4461 ; hsa-mir-519d-5p ; hsa-mir-604 ; hsa-mir-647 ; hsa-mir-6762-3p ; hsa-mir-6772-3p ; hsa-mir-6885-3p ; hsa-mir-7853-5p ; hsa-mir-889-5p
Nearest miRNA
hsa-mir-3125/Upstream/5221547; hsa-mir-10b/Downstream/758588;
Nearest TSS
ENST00000437798/Upstream/5742; ENST00000483904/Downstream/14424;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/77753, chr2-CpG: 68/Downstream/222958
Nearby gene
NCOA1(+14425) ;
Upstream sequence
acttcccagagtcaaaatgcaagcagaaagtagattaggagtccttttttcaatttctcaagttgaagcacttaatttccagctttaagtggtatatact
Downstream sequence
tttttttttttttttttttagcattcaaaggaatgctgaaattaaaaatcagtgagaagtcttgctatataatttctgggtccacgttcaatcataatat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate