Basic Information
VIS ID
TVIS44013721
Fusion event
HTLV-1-LY75 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
160753933/159897422 (Hg38)
End
160753933/159897422 (Hg38)
Orient
-
Location type
Intronic
Target gene
LY75
miRNAs that regulate target gene
hsa-mir-16-2-3p ; hsa-mir-195-3p ; hsa-mir-3672 ; hsa-mir-4690-3p ; hsa-mir-4786-5p ; hsa-mir-5583-3p ; hsa-mir-5685 ; hsa-mir-6864-3p ; hsa-mir-769-5p
Nearest miRNA
hsa-mir-128-1/Upstream/710521; hsa-mir-10b/Downstream/510388;
Nearest TSS
ENST00000437798/Upstream/99167; ENST00000477952/Downstream/7227;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/99042, chr2-CpG: 79/Downstream/6671
Upstream sequence
TCTTAGTTGGCAAGTTGGAGAAGGGCTTTTGTGGCACAGAATTTAAATTTGCCATTAAGTCATATCCAAAAAGCAACTGCTTTACTTTTAGGAGGAAACT
Downstream sequence
GGCTCGCAGAAACAGACTGTCAACTATTCAAAGGCCAGGGAATGATGAAAAGGAAACCCTATCTCTAATTCTCTAATATTTCTCCACAACAGAACTTGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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