Basic Information
VIS ID
TVIS44013722
Fusion event
HTLV-1-TBR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
162282235/161425724 (Hg38)
End
162282235/161425724 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBR1
miRNAs that regulate target gene
hsa-mir-542-5p ; hsa-mir-6889-5p ; hsa-mir-6777-5p ; hsa-mir-3162-3p ; hsa-mir-6777-3p ; hsa-mir-7151-5p ; hsa-mir-181c-3p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-128-1/Upstream/1017842; hsa-mir-10b/Downstream/7157219;
Nearest TSS
ENST00000437798/Upstream/1351; ENST00000606386/Downstream/1729;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1526, chr2-CpG: 82/Downstream/1346
Nearby gene
TBR1(+662) ;
Upstream sequence
TCATACACAATATTCAATCTAGATTCCAGTCCATGGGGGGATTTTTCCTAATAGGAATTCAGGGTCTAAACGTGTGTATATTTTGGCTCTTCTGTAAATC
Downstream sequence
TAATGTTGTGATTTTTATATTTGTTTCGTTTTGTCTGTGAACTGAATAATTTATACAAGAACACACTCCATTGAGAAACGTTTTGTTTTTTGCTCGTTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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