Basic Information
VIS ID
TVIS44013734
Fusion event
HTLV-1-CDH12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
22776680/22776571 (Hg38)
End
22776680/22776571 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5E
Target gene
CDH12
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-8068 ; hsa-mir-6867-5p ; hsa-mir-574-5p ; hsa-mir-759 ; hsa-mir-4433a-5p ; hsa-mir-4433b-5p ; hsa-mir-4646-3p
Nearest miRNA
hsa-mir-10397/Upstream/5620579; hsa-mir-103a-1/Downstream/9159531;
Nearest TSS
ENST00000502646/Upstream/137577; ENST00000507674/Downstream/76770;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1316828, chr5-CpG: 68/Downstream/2413823
Upstream sequence
GCAATTATAGTACAATATGGTAATGCCTATGATAATTGCGTACACAGAGCTCTATAGGCACAGAAGGAAATCTGTGTAACAACACTCTGAGATGAGGAAG
Downstream sequence
GATTTTCAGAAAGAAGTTTATTCTAAATTTAGTTAGAGAAACAGGATTCTTCTAGAAAAAAATAGGAATGATCTGGGGGTTGTGAGAAATTTTAGAACTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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