Basic Information
VIS ID
TVIS44013739
Fusion event
HTLV-1-OFCC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
9979257/9979024 (Hg38)
End
9979257/9979024 (Hg38)
Orient
+
Location type
Intronic
Target gene
OFCC1
miRNAs that regulate target gene
hsa-mir-181a-5p
Nearest miRNA
hsa-mir-3691/Upstream/3809589; hsa-mir-10398/Downstream/460693;
Nearest TSS
ENST00000381078/Upstream/817247; ENST00000645232/Downstream/425478;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/579658, chr6-CpG: 35/Downstream/340424
Nearby gene
TFAP2A(-417659) ;
Upstream sequence
caggcagtttattgtcaggtatatgttctCTGCTCTTCCTTGTCTTGTCATGAGGGTAGTACCTGTTGTACATGGTTGGATATTAACCAGTGTAAACTGC
Downstream sequence
CCTCCACCACCAGGAATACAGAAACATACCACAGCCAGTGGAAAATGAGAAAGATGAAAAAAGAGGGACTAGAGATTCCTAGCTAACATTGTAAACATTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate