Basic Information
VIS ID
TVIS44013748
Fusion event
HTLV-1-EIF3E integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
109233732/108221503 (Hg38)
End
109233732/108221503 (Hg38)
Orient
-
Location type
Intronic
Target gene
EIF3E
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-16-5p ; hsa-mir-29a-3p ; hsa-mir-218-5p ; hsa-mir-335-3p ; hsa-mir-452-3p
Nearest miRNA
hsa-mir-12123/Upstream/3737038; hsa-mir-10400/Downstream/4421990;
Nearest TSS
ENST00000518652/Upstream/18157; ENST00000520037/Downstream/4697;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/137882, chr8-CpG: 43/Downstream/26794
Nearest cancer related gene
EIF3E(OG, No orient, 0)
Upstream sequence
ttgctttcctgtcagtttgagaacatgtgacagttgtgataagtgattatagtccggtaatgtggatgtatattattagcttacctacagtgtcagttta
Downstream sequence
gtactttgctttgtaattcctacaataaaaatctccactccactgtgctttataatcatagtcgaagttcacttctctgttttgacacggtaaataagca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate