Basic Information
VIS ID
TVIS44013758
Fusion event
HTLV-1-SORCS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
106439570/104679812 (Hg38)
End
106439570/104679812 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SORCS3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-107/Upstream/411407; hsa-mir-202/Downstream/6218278;
Nearest TSS
ENST00000439456/Upstream/13612; ENST00000393176/Downstream/479116;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/36758, chr10-CpG: 100/Downstream/2484210
Upstream sequence
GAGGGCTCTTGATTGCAACATTCCATTTCTTTCCTTCTGCCTTGGTGGAGGGTTTCAGAGAGCCTTCTGTTGACCTTCTTTTAATTGCTAATAATTATTC
Downstream sequence
AATTTTATATAGCCCACAGTGATAAATATTCATGAAAAGCACAGTGTATCAAGATCCAACACTTTAAGCTATTGTGTTTTTTTAATTAAACTGAAACATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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