Basic Information
VIS ID
TVIS44013785
Fusion event
HTLV-1-HPCAL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
10468126/10328000 (Hg38)
End
10468126/10328000 (Hg38)
Orient
+
Location type
Intronic
Target gene
HPCAL1
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-3976 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4745-3p ; hsa-mir-1538 ; hsa-mir-873-5p ; hsa-mir-6746-5p ; hsa-mir-6784-5p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-4747-3p ; hsa-mir-6165 ; hsa-mir-2278 ; hsa-mir-1249-5p ; hsa-mir-125a-3p ; hsa-mir-1321 ; hsa-mir-3197 ; hsa-mir-3934-5p ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-4779 ; hsa-mir-5587-5p ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6797-5p ; hsa-mir-6801-5p ; hsa-mir-6880-5p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-764 ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-4261/Upstream/135329; hsa-mir-10b/Downstream/1212605;
Nearest TSS
ENST00000437798/Upstream/3653; ENST00000422133/Downstream/2163;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/23617, chr2-CpG: 54/Downstream/91590
Upstream sequence
ccccggatccataactttcatttcctgacTGATATATCAGAAGCTTCATGTATAAAGGCGCATTAGATTTAGTAAGTGTAAAAGACTTAAGTTGAGGTCA
Downstream sequence
TTTCTGTCCACAAGCTGTTCATGGTGTAGCTGTTCATGTAGCTCAGCTGTGGGAATGGCCTGGCCCTATGTGATGCGGAAAGACAGCCAAGGGGGACAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate