Basic Information
VIS ID
TVIS44013812
Fusion event
HTLV-1-EPB41L4A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
111727461/112391764 (Hg38)
End
111727461/112391764 (Hg38)
Orient
-
Location type
Intronic
Target gene
EPB41L4A
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10397/Upstream/1877849; hsa-mir-103a-1/Downstream/3863979;
Nearest TSS
ENST00000502646/Upstream/84362; ENST00000624967/Downstream/1020;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/230421, chr5-CpG: 194/Downstream/27016
Upstream sequence
ttatccaggagaactttcccaacctagcaaggcaggtcaacattcaaattcaggaaatacagagaacaccatagatactcctcaagaagagcaaccccaa
Downstream sequence
gacacataattgtcagattcaccaaggttgaaatgaaggaaaaaatgttaagggcagtcagagagaaaggtcgggttacccacaaaggcccatcagacta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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