VISDB - VIS Detail

Basic Information

VIS ID

TVIS44013823

Fusion event

HTLV-1-POLM integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr7

Cytoband

p13

Reference genome

GRCh37/hg19

Start

44119017/44079418 (Hg38)

End

44119017/44079418 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA7D

Target gene

POLM

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-218-5p ; hsa-mir-6879-3p ; hsa-mir-6773-3p ; hsa-mir-500b-3p ; hsa-mir-4448 ; hsa-mir-4645-3p ; hsa-mir-1324 ; hsa-mir-4642 ; hsa-mir-324-5p ; hsa-mir-212-5p ; hsa-mir-1224-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-4733-5p ; hsa-mir-512-3p ; hsa-mir-6813-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-640 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3663-5p ; hsa-mir-3653-5p ; hsa-mir-5089-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-6504-3p ; hsa-mir-1273c ; hsa-mir-3145-5p ; hsa-mir-3613-3p ; hsa-mir-515-5p ; hsa-mir-519d-5p ; hsa-mir-519e-5p ; hsa-mir-5695 ; hsa-mir-5708

Nearest miRNA

hsa-mir-1183/Upstream/5985; hsa-mir-10399/Downstream/31431;

Nearest TSS

ENST00000635602/Upstream/2392; ENST00000449162/Downstream/506;

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/13901, chr7-CpG: 82/Downstream/2839

Upstream sequence

AACAGTGTCACCCCTAGCCCTGCCAGGCCCCTCACAGCGCCATTCACTGGGTCCTCTAGGCCACCCAGGAGTAAATGGCTAGTGTGCACAGGAGGAATCT

Downstream sequence

GAGCGCAGAGGGTGGCTTGTTGAGGCCTTGGAGCAGTGTCAGCACCCACGACTGTCTGTCCTCACCCACCCCCACAGCACCCTCTGCTGTCTCACCAGGC

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.