Basic Information
VIS ID
TVIS44013850
Fusion event
HTLV-1-ARHGAP15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
144023797/143266228 (Hg38)
End
144023797/143266228 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
ARHGAP15
miRNAs that regulate target gene
hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-6807-5p ; hsa-mir-4698 ; hsa-mir-586 ; hsa-mir-5700 ; hsa-mir-3662 ; hsa-mir-4764-3p ; hsa-mir-3134 ; hsa-mir-4495 ; hsa-mir-1246 ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426 ; hsa-mir-8087 ; hsa-mir-6750-3p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa
Nearest miRNA
hsa-mir-128-1/Upstream/2679543; hsa-mir-10b/Downstream/6064050;
Nearest TSS
ENST00000437798/Upstream/18938; ENST00000548800/Downstream/169036;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1135244, chr2-CpG: 111/Downstream/670535
Upstream sequence
AAAAATATCTAATTTATGGTTAGGAAACTGAATAACAGTCAACTATTTCCCATTGTTTCCCACTAAGTCCTTTGTTCCACAGTTACTTTAAATAAATTTT
Downstream sequence
CTCACTTCATATAAAATGCCCTTTTGATAATACTGTCAATTTATCTTCTAAAGTCAAGCAAAATTAATTTTTTCAATATAATACAAATCAAACTATGGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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