Basic Information
VIS ID
TVIS44013857
Fusion event
HTLV-1-AHRR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
393433/393318 (Hg38)
End
393433/393318 (Hg38)
Orient
+
Location type
Intronic
Target gene
AHRR
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26a-5p ; hsa-mir-18a-5p ; hsa-mir-125b-5p
Nearest miRNA
hsa-mir-10397/Downstream/669578;
Nearest TSS
ENST00000502646/Upstream/49790; ENST00000510910/Downstream/27602;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/796, chr5-CpG: 51/Downstream/27791
Nearest cancer related gene
AHRR(TSG, No orient, 0)
Upstream sequence
GCCGGCACAGACGCGTCCTCCGGCCCTCCCCACGTTGGCAGCACGTTGACTGTGTCTGAAGCTTAATCCCGATGTCACAGATTCTTGTCTTTGCACCTAA
Downstream sequence
CGTTACGTGTCTCATCCAGCCCAGGGCACCCGATCACGTCGCTCACTAACCGATCCTTCCTCCTCCCGAGTGTTCCTCTAGCAGTCTGCTGTGGGCCTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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