Basic Information
VIS ID
TVIS44013858
Fusion event
HTLV-1-ADAMTS12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
33560291/33560186 (Hg38)
End
33560291/33560186 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
ADAMTS12
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10397/Upstream/1165711; hsa-mir-103a-1/Downstream/2587706;
Nearest TSS
ENST00000502646/Upstream/37956; ENST00000330120/Downstream/64165;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/57928, chr5-CpG: 25/Downstream/331900
Upstream sequence
ATAGAAATAGCATTGCATGCTGGAGAAGCAATTAATAACCCAAACTTAACTTTTCTGGTTTATCTTGTAAGAGAAAGGACAGGTGGGTTACCACATGTGG
Downstream sequence
GTTAATAAAAACTCTGTACTTCTAAGACTTTTGTGTAACTTGAAGTTGGCCTATGGTAATGCCCATGATTTGCTCATCCCTGATTTTATAAGAGGTAAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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