Basic Information
VIS ID
TVIS44013862
Fusion event
HTLV-1-CARD11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
3035313/2995679 (Hg38)
End
3035313/2995679 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
CARD11
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-330-5p ; hsa-mir-146b-5p ; hsa-mir-218-5p ; hsa-mir-539-5p
Nearest miRNA
hsa-mir-339/Upstream/468534; hsa-mir-10399/Downstream/1792886;
Nearest TSS
ENST00000635602/Upstream/51644; ENST00000478527/Downstream/48166;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/66717, chr7-CpG: 35/Downstream/47828
Nearest cancer related gene
CARD11(OG, No orient, 0)
Upstream sequence
atttgatgttcactatttgggtgatgggttcagtagaattccaaacctgagcattatgcaatgtccctatgtcacacacaaacctgcacatgtacccccg
Downstream sequence
gaatctaaaatttccaaaaagagaaacaataactaaaaagaaaaaccaatcactccctgcttaaaggccccatctccaaatacaatcacattgggagttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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