Basic Information
VIS ID
TVIS44013883
Fusion event
HTLV-1-CNTNAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
145817210/146120118 (Hg38)
End
145817210/146120118 (Hg38)
Orient
+
Location type
Intronic
Target gene
CNTNAP2
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-99b-5p ; hsa-mir-4444 ; hsa-mir-6079 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4428 ; hsa-mir-571 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-mir-10399/Upstream/2737318; hsa-mir-153-2/Downstream/1257899;
Nearest TSS
ENST00000635602/Upstream/2858; ENST00000636600/Downstream/654153;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/3126, chr7-CpG: 33/Downstream/2219284
Nearest cancer related gene
CNTNAP2(TSG, No orient, 0)
Upstream sequence
AAACACCATTCAAGGAATTTAAGTTGTTTACAAGTTTATAGAAAGGTCTTTTTCCAGTGCAATTATTTTAAGTAACTAACGCAACAATATTAAGCAATAG
Downstream sequence
TATATTAGTCTATTTTCTCTTCCTCAATTCATATACTTCTCCCAAAATGGTGTATTTTAAATGTAAAATATGTAAATGCATATAAAAGCAAATACTGCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate