Basic Information
VIS ID
TVIS44013897
Fusion event
HTLV-1-LOC105373909 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q36.2
Reference genome
GRCh37/hg19
Start
225490178/224625461 (Hg38)
End
225490178/224625461 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105373909
Nearest miRNA
hsa-mir-10b/Upstream/4718896; hsa-mir-1244-1/Downstream/385000;
Nearest TSS
ENST00000437798/Upstream/40064; ENST00000636099/Downstream/90904;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/39690, chr2-CpG: 114/Downstream/416475
Nearby gene
CUL3(-40064) ;
Upstream sequence
GGTTGGGGGCAGGGGTGCATCTTTTTGTAAAGTGAATTAAAACAATGACAGTGTTTTTATTTGCGATCAACTTTTATAATAAGACTCCATCTTTTTTTAC
Downstream sequence
TTCTTTATTACAGGGAAGTCAGAAAATACACATACACATAAAGAAGTCAAGACCACCCACCCGCCACCCTTTTTGAGACGGCTGCCATTAACAGCCATCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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