Basic Information
VIS ID
TVIS44013910
Fusion event
HTLV-1-AIDA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
222877383/222704041 (Hg38)
End
222877383/222704041 (Hg38)
Orient
-
Location type
Intronic
Target gene
AIDA
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-4460 ; hsa-mir-6828-5p ; hsa-mir-140-5p ; hsa-mir-6718-5p ; hsa-mir-203b-5p ; hsa-mir-6755-5p ; hsa-mir-4433b-3p ; hsa-mir-6510-5p ; hsa-mir-3121-3p ; hsa-mir-1208 ; hsa-mir-1304-3p ; hsa-mir-202-3p ; hsa-mir-329-5p ; hsa-mir-3653-3p ; hsa-mir-3665 ; hsa-mir-4477b ; hsa-mir-513b-5p ; hsa-mir-5197-3p ; hsa-mir-657 ; hsa-mir-6755-3p ; hsa-mir-6760-3p ; hsa-mir-7856-5p
Nearest miRNA
hsa-mir-101-1/Upstream/2503422; hsa-mir-1182/Downstream/1552999;
Nearest TSS
ENST00000473358/Upstream/27823; ENST00000496267/Downstream/8222;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/59712, chr1-CpG: 70/Downstream/7943
Upstream sequence
AAACTATGGTctcaactataaaaagaccaattttggacaaaggatttgaatagatagttctccaaagaagacataaaatggtcaataagcacatgaaaag
Downstream sequence
atgatcaacattactagtcattatgaaaacacagatcaaaatcacaatgagctatcacttcatacccactagaatgagtacaattttttaaaaaatggaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate