Basic Information
VIS ID
TVIS44013915
Fusion event
HTLV-1-GALNT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
33288668/35708704 (Hg38)
End
33288668/35708704 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
GALNT1
miRNAs that regulate target gene
hsa-mir-129-5p ; hsa-mir-30a-5p ; hsa-mir-10a-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-323a-3p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-577 ; hsa-mir-590-3p ; hsa-mir-922 ; hsa-mir-548e-5p ; hsa-mir-6838-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-192-3p ; hsa-mir-224-5p ; hsa-mir-1273e ; hsa-mir-636 ; hsa-mir-4704-3p ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6832-3p ; hsa-mir-141-5p ; hsa-mir-5585-3p ; hsa-mir-3145-5p ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-1-2/Upstream/116898; hsa-mir-122/Downstream/196114;
Nearest TSS
ENST00000575820/Upstream/54048; ENST00000590983/Downstream/7666;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/126404, chr18-CpG: 53/Downstream/241261
Upstream sequence
GTAGAGTAATGCTTAATGCACATTCCTGTATACAACTACTTTGAAGTCCTTAACATGACCAGAGCATATTATCACAATCATTGGTGTGGATCATTGTTAA
Downstream sequence
CTATCTATCTGTTAATTCTTACCTGCCCTGCCCTTTCAAAATTATCCTAATAACATGTTGCTGCATCAAATCTAGAACTTAAATAAGTGGATAAAATATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate