Basic Information
VIS ID
TVIS44013920
Fusion event
HTLV-1-ARHGAP10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.23
Reference genome
GRCh37/hg19
Start
148694152/147773001 (Hg38)
End
148694152/147773001 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP10
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-214-3p
Nearest miRNA
hsa-mir-12113/Upstream/428284; hsa-mir-1305/Downstream/9594;
Nearest TSS
ENST00000502981/Upstream/40938; ENST00000513548/Downstream/87982;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/40234, chr4-CpG: 294/Downstream/669059
Upstream sequence
AGTCATTGGGTGGGCGGAACTGATTAGAATTCCAAAAGCAATACATATAGGAGTTAGGTGGAACTCTTTTGGAATTAAGTAGGAAAGATTTTGACGGAAC
Downstream sequence
TCCTGCATTCCAGAGTTCAGTGGTAAAAAGAACACTTTATGTACAGAGTATTTGGGTAAATGTCTTCTGCATTTTGCTTTAGTTTTTTCTTTGTTGGTAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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