Basic Information
VIS ID
TVIS44013923
Fusion event
HTLV-1-CREB5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
28471180/28431561 (Hg38)
End
28471180/28431561 (Hg38)
Orient
-
Location type
Intronic
Target gene
CREB5
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-125a-5p ; hsa-mir-10a-5p ; hsa-mir-32-5p ; hsa-mir-6832-3p ; hsa-mir-182-5p ; hsa-mir-8485 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-1179 ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-147a ; hsa-mir-29b-2-5p ; hsa-mir-155-3p ; hsa-mir-6867-5p ; hsa-mir-644a ; hsa-mir-3911 ; hsa-mir-1273g-5p ; hsa-mir-203a-5p ; hsa-mir-92a-1-5p ; hsa-mir-374c-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-323b-3p ; hsa-mir-5195-5p ; hsa-mir-651-3p ; hsa-mir-590-5p ; hsa-mir-29c-3p ; hsa-mir-449a ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-3681-3p ; hsa-mir-4672 ; hsa-mir-6768-5p
Nearest miRNA
hsa-mir-1183/Upstream/1261998; hsa-mir-10399/Downstream/1249173;
Nearest TSS
ENST00000635602/Upstream/19036; ENST00000468391/Downstream/4054;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/21608, chr7-CpG: 53/Downstream/422275
Upstream sequence
GTTGCAATCAGTAAACAACCCTGATTTTTTCTTTTGCTTGTGGCACTGGCTCATGCTTGGACATTTACACTCTTTATTTAGCAAGAAAGCATTTGAAAGG
Downstream sequence
TACCTTTCAAATATTGGAGGTAAACAAAGGTCAGTCTTTCCTAAGCAAGAGTAGCAAAATTAAAAATATGTTAATTTTAACTTGCCGGTTCACAGATTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate