Basic Information
VIS ID
TVIS44013924
Fusion event
HTLV-1-PHKG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
56149900/56082207 (Hg38)
End
56149900/56082207 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA7A
Target gene
PHKG1
miRNAs that regulate target gene
hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1292-5p ; hsa-mir-6780b-3p ; hsa-mir-4780
Nearest miRNA
hsa-mir-1183/Upstream/11200407; hsa-mir-10399/Downstream/873578;
Nearest TSS
ENST00000635602/Upstream/5604; ENST00000566570/Downstream/5486;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/17674, chr7-CpG: 48/Downstream/24012
Upstream sequence
TACTTCCTCCCTTGCCCAGCCTAGCTGGGTGCTCCTCCTTTCCCGGCGCACTCACATGTCCACCTCTTTCCCGTAGCCCGGGTGGTCCTCATTCATGGAG
Downstream sequence
CACTCGATAATCTCAGGGGCCAGGTAACTGGGGGTCCCGCAGACCTCTGCAGGAACAGTCATCATCAGGGCAGGTCAGCAGGGCACTCAGAAGAGGAAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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