Basic Information
VIS ID
TVIS44013931
Fusion event
HTLV-1-TOX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
60029271/59116712 (Hg38)
End
60029271/59116712 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOX
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-223-3p
Nearest miRNA
hsa-mir-124-1/Upstream/16220437; hsa-mir-10400/Downstream/2598076;
Nearest TSS
ENST00000518652/Upstream/456868; ENST00000523683/Downstream/2328;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/456745, chr8-CpG: 175/Downstream/863
Upstream sequence
AAATATATCTGATGGACTGCTACACAGAGATGGGCCAGAGATGTCCCTGGAGAAACATTTCCATGAAGTCTTCTTCCACTATTAGAAACATGTCTTATGA
Downstream sequence
CTTTGGATTTTAAAAAATCTATTATTCTCTGGATAAGTTAAATAGAAGACTCGCAACTAGTCTACAGAAAGGGTGCCTAATTTGCATTTAAAAAGAACAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate